Frequently Asked Questions about LubriSyn CA™
What is LubriSyn CA made from?
The purified hyaluronan in LubriSyn CA is extracted from a microbial source. Other oral hyaluronan (HA) products are made from things such as rooster combs or chicken cartilage. The microbial biofermentation results in a high molecular weight HA, and keeps it free from proteins, dermatan, chondroitin sulfate and other glycosaminoglycan contamination that may be found in other HA products.
Where can I get LubriSyn CA?
LubriSyn CA is currently available online at lubrisyn.com and through our toll-free customer service line 800-901-8498.
How is LubriSyn CA administered?
LubriSyn CA is administered orally to your pet. Many pet owners put LubriSyn CA directly on their pet's food.
Is there proof that it gets into the joint?
What is Adequan® Canine?
LubriSyn CA is an daily oral hyaluronan joint supplement. Adequan Canine is an injectable drug given by veterinarians to dogs to help improve joint function. Adequan is a polysulfated glycosaminoglycan that can increase production of joint hyaluronan. It is recommended by Novartis Animal Health to be given twice a week for four weeks; each injection has a duration of effect lasting about three days. (Novartis 2005) Pets can still be given Lubrisyn CA while receiving Adequan.
Is LubriSyn CA like Cosequin®?
No. LubriSyn CA is beneficial to the joint fluid. Cosequin is composed primarily of glucosamine and chondroitin sulfate and works on cartilage. (NutraMax Laboratories, Inc. 2005) LubriSyn CA and Cosequin can work synergistically to improve joint health.
How much should I give?
The recommended daily oral dose for dogs is 1 teaspoon (5 ml) for dogs up to 30 pounds body weight. For dogs between 30 and 60 pounds, we suggest 1 ½ teaspoons daily. For dogs between 60 and 100 pounds, 2 teaspoons. The amount may be doubled for hard-working dogs.
How can LubriSyn CA benefit my dog?
LubriSyn CA provides viscosupplementation and is intended to help dogs and cats have as healthy joints as possible.
What does LubriSyn CA taste and smell like?
LubriSyn CA is basically odorless and tasteless. Since LubriSyn CA contains sodium hyaluronate, it might have a very slight salty taste to some very sensitive palates.
Can I give too much?
Our safety studies have shown that even at five times the recommended dose for 60 days, there were no adverse effects.
How long will it be before I see results?
There is no exact time. Most animals respond by seven to 14 days. Results vary depending upon the condition of the joints.
How much does it cost?
LubriSyn CA is available only through veterinarians. LubriSyn CA (Allday Products) does not set the retail price. LubriSyn CA comes in an 8.5 ounce (251 ml) bottle that should last a 30-60 pound dog about thirty days.
What if I feel it is not working?
Your pet may need a slightly higher daily amount depending upon the condition of their joints. First, try a double dose for one week to see if there is any noticeable improvement. If there is no change, continue the double-dose for an additional week. If symptoms persist, contact your local veterinarian or call 1-800-901-8498 to speak with one of our experts.
Will my animal eat it?
We know of no problems with acceptance of LubriSyn CA. It is odorless and basically tasteless; some very sensitive palates may detect a slight salty taste.
Will LubriSyn CA go bad?
We suggest using the freshest product possible, but if handled properly it will last 12 months. LubriSyn CA is a sensitive product and can deteriorate. We have added a minimal amount of preservatives to avoid any deterioration. We have also taken steps during production and shipping to ensure its integrity. The production date is printed on the label.
Will extreme temperatures hurt LubriSyn CA?
Yes. As with most liquid nutritional supplements, extreme hot or cold temperatures can cause some breakdown. We recommend storing LubriSyn CA between 40 and 90 degrees Fahrenheit (4 to 32 degrees centigrade). DO NOT freeze LubriSyn CA.
Are there any drugs in LubriSyn CA?
No. Hyaluronan is a naturally occurring substance found in the joints, skin and other tissues of all mammals. LubriSyn CA is made from a microbial source of hyaluronan along with a very small amount of sodium benzoate and potassium sorbate as protectants.
Does food affect LubriSyn CA?
LubriSyn CA can be given orally with a meal or between meals. The food should have no effect.
What is the difference between hyaluronan, sodium hyaluronate and hyaluronic acid?
These are three different names for the same compound.
References
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Cantor, JO, and PP Nadkarni. "Hyaluronan: the Jekyll and Hyde molecule." Inflamm Allergy Drug Targets 5, no. 4 (Dec 2006): 257-260.
Gotoh, S, et al. "Effects of the molecular weight of hyaluronic acid and its action mechanisms on experimental joint pain in rats." Ann Rheum Dis 52, no. 11 (Nov 1993): 817-822.
Ishimaru, JI, N Ogi, S Mizuno, and AN Goss. "Quantitation of chondroitin-sulfates, disaccharides and hyaluronan in normal, early and advanced osteoarthritic sheep temporomandibular joints." Osteoarthritis Cartilage 9, no. 4 (May 2001): 365-370.
Moreland, LW. "Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action." Arthritis Res Ther 5, no. 2 (2003): 54-67.
Nakamura, K, et al. "High, but not low, molecular weight hyaluronan prevents T-cell-mediated liver injury by reducing proinflammatory cytokines in mice." J Gastroenterol 39, no. 4 (2004): 346-354.
Novartis. Clinical Studies. 2005. http://www.adequancanine.us/vet/en/vet_clinicalStudies.shtml (accessed Feb 22, 2007).
NutraMax Laboratories, Inc. 2005. http://www.nutramaxlabs.com/Brochures/Cosequin Dog Brochure.pdf (accessed Feb 22, 2007).
Ohkawara, Y, G Tamura, T Iwasaki, A Tanaka, T Kikuchi, and K Shirato. "Activation and transforming growth factor-beta production in eosinophils by hyaluronan." Am J Respir Cell Mol Biol 23, no. 4 (Oct 2000): 444-451.
Schauss, AG, LG Balogh, AG Polyak, RG Kiraly, and i GG Janok. "Absorption, distribution and excretion of 99mtechnetium labeled hyaluronan after single oral doses in rats and beagle dogs." FASEB j 18, no. 4 (2004): A150-151.
Takahashi, T, et al. "A decreae in the molecular weight of hyaluronic acid in synovial fluid from patients with temporomandibular disorders." J Oral Pathol Med 33, no. 4 (Apr 2004): 224-229.
Yeung, RW, RL Chow, Samman N, and K Chiu. "Short-term therapeutic outcome of intra-articular high molecular weight hyaluronic acid injection for non-reducing disc displacement of the temporomandibular joint." Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102, no. 4 (Oct 2006): 453-461.
